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KMID : 0379520090250010047
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한국독성학회지
2009 Volume.25 No. 1 p.47 ~ p.50
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Genotoxic Evaluation of Surfactin C in Chinese Hamster Lung Cell Line
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Lim Jong-Hwan
Yun Hyo-In
Kim Myoung-Seok
Hwang Youn-Hwan
Park Byung-Kwon
Song In-Bae
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Abstract
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To investigate the mutation inducibility of surfactin C, we performed the chromosome aberration assay with Chinese hamster lung cells in vitro. The colorimetric MTT screening assay was carried out to determine the cytotoxicity index () of surfactin C. The value was . For the chromosome aberration test of surfactin C, the maximum concentration was employed as , followed by 62.5 and for the lower concentrations, with or without metabolic activation (S9). Cyclophosphamide and mitomycin C were used as positive controls in the presence and absence of S9 metabolic activation, respectively. These results showed that surfactin C was not capable of inducing chromosome aberration, as measured by the chromosome aberration test using Chinese hamster lung cell line. There is no evidence for surfactin C to have a genotoxic potential.
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KEYWORD
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Surfactin C, Chromosome aberration test, MTT test, Chinese Hamster Cell
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